What is Novolin ge 50/50 PenFill Cartridge?
Novolin ge 50/50 PenFill is a cartridge filled with a mixture of 50% Regular human insulin and 50% NPH insulin suspension for your reusable insulin pen. Both are man-made insulin analogs, which have a similar effect and action as naturally occurring human insulin does. They are both used separately in the treatment of diabetes for the management of high blood sugar levels. Regular insulin is a short-acting mealtime insulin, and NPH insulin is an intermediate–acting background insulin. When combined together, they protect you against high blood sugar spikes during and after meals, and also between meals and during nighttime.
What is it used for?
Novolin ge 50/50 PenFill Cartridge is used for the control of high blood sugar levels in the treatment of diabetes. The cartridges are made to be loaded in your reusable insulin delivery pen. The fast-acting Regular insulin together with the intermediate-acting NPH insulin provides you with a whole day’s worth of insulin control for your blood sugar levels.
How does it work?
Diabetes is a disorder that arises from either your pancreas not producing enough insulin, or because your body does not properly respond to the insulin that it does produce. Insulin itself is a digestive hormone that is primarily involved in controlling your metabolism. It controls your blood sugar levels by regulating the breakdown of food, like fats, sugars and proteins. It helps take the sugar out of your blood and into your liver, fat, and skeletal muscle cells where the sugar can be used as energy.
Novolin ge 50/50 mix has been designed to have a very similar action to that of naturally occurring human insulin. The specific activity profile of the 50/50 mix is a result of the mixture of both the Regular and NPH insulin. It combines the fast-acting onset of Regular insulin, which begins to work in 30 minutes, along with the intermediate-acting duration of NPH insulin, which can last up to 24 hours.
Common negative effects may include:
- Injection site reactions
- Allergic reactions
- Hypoglycemia (low blood sugar)
- Lipoatrophy, Lipohypertrophy
- Edema (swelling of your hands and feet)
- Vision changes
- Heart Failure (if used with TZDs)
Symptoms of hypoglycemia (low blood sugar) may include:
- Tingling of lips and tongue
- Anxiety, irritability or mood changes
- Fast heart beat
- Trouble concentrating or confusion
- Slurred speech
- Lightheadedness or dizziness
- Blurred vision
Repeated subcutaneous injections of insulin can result in injection site reactions. Some of the problems associated with repeated injections are swelling, itching and redness around the injection site. If you continue to have problems with your skin around the injection site, or it becomes worse, contact your doctor. Do not administer your insulin into skin that is red, itchy or swollen.
The signs of a potentially serious allergic reaction include
- rapid heartbeat
- rash over your whole body
- trouble breathing.
If you experience any of these side effects, contact your doctor immediately.
Some users have reported side effects of lipoatrophy, which is the localized loss of fat around the injection site, and lipohypertrophy, which is the localized accumulation of fat at the injection site. To prevent these types of skin conditions from occurring, remember to change your injection site every time you administer your insulin. Never inject your insulin into any type of skin that is visibly irritated.
Insulin therapy has the potential to shift your potassium (K+) levels in your blood. An abnormally low level of potassium in your blood is called hypokalemia, which can be a potentially serious side-effect. Symptoms of hypokalemia may include leg cramps, constipation, weakness and feeling tired.
Heart failure has been reported in some people who are taking antidiabetic drugs called thiazolidinediones (TZDs) along with Novolin ge 50/50. This combination can cause serious heart issues, even if you have never had any heart problems before. If you have had some heart problems in the past, this can make them worse. Contact your doctor if you have any symptoms of heart failure, which may include:
- Swelling in your feet or ankles
- Sudden weight gain
- Shortness of breath
How to take this medication
Make sure that your Novolin ge 50/50 PenFill Cartridges are not damaged. The insulin is the cloudy material, which may have settled at the bottom of the cartridge, so it must be rotated up and down until the suspension in the cartridge are uniformly mixed before you administer a dose. Insulin Novolin ge 50/50 PenFill comes in a 3 mL cartridge for use with your reusable insulin pen.
Your dose schedule was personalized specifically for you by your doctor based on your specific metabolic needs, blood sugar level monitoring, type of diabetes and your history of diabetes treatment including your previous use of insulin. Many factors can affect your dose, some of which include changes in your diet, activity level or work schedule. Other factors that can affect your dose and schedule are pregnancy, illness, medication and travel. You should always monitor your blood sugar levels closely, especially if you are switching to Novolin ge 50/50 from another insulin.
Your doctor has determined the strength, type and amount of insulin you should be taking and your specific dosing schedule. You may not be on a strict time dose schedule with Novolin ge 50/50, but you need to eat your meal within 45 minutes of administration. Never use a larger dose to make up for any previously skipped dose.
Warnings and Precautions
Do not take it if you:
- Have allergies to anything in the mixture
- Think you may have hypoglycemia (low blood sugar)
Make sure to inform your doctor:
- About any of the medicines you are currently taking, including prescription and non-prescription medications, vitamins and any supplements
- About any of your medical conditions
- If you are pregnant, are planning to become pregnant or are breastfeeding
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